Publications

Recent Publications

Céspedes N, Donnelly EL, Hansten G, Fellows AM, Dobson M, Kaylor HL, Coles TA, Schauer J, Van de Water J, Luckhart S. Mast cell-derived IL-10 protects intestinal barrier integrity during malaria in mice and regulates parasite transmission to Anopheles stephensi with a female-biased immune response. Infect Immun. 2024 Feb 1:e0036023.

Riske BF, Luckhart S, Riehle MA. Starving the Beast: Limiting Coenzyme A Biosynthesis to Prevent Disease and Transmission in Malaria. Int J Mol Sci. 2023 Sep 10;24(18):13915.

Coles TA, Briggs AM, Hambly MG, Céspedes N, Fellows AM, Kaylor HL, Adams AD, Van Susteren G, Bentil RE, Robert MA, Riffell JA, Lewis EE, Luckhart S. 2023. Ingested histamine and serotonin interact to alter Anopheles stephensi feeding and flight behavior and infection with Plasmodium parasites. Front Physiol. 14:1247316. doi: 10.3389/fphys.2023.1247316.

Stefanovska T, Luckhart S, Ripa L, Stevens G, Lewis E. 2023. Steinernema carpocapsae. Trends Parasitol. 39(5):400-401. doi: 10.1016/j.pt.2023.01.002.

Oyieko J, Copeland NK, Otieno S, Kifude C, Ocholla S, Hutter J, Smith H, Roberds A, Luckhart S, Stewart VA. Longitudinal and Cross-sectional Analyses of Asymptomatic HIV-1/Malaria Co-infection in Kisumu County, Kenya. Am J Trop Med Hyg. 2022 Nov 21:tpmd220035. doi: 10.4269/ajtmh.22-0035. Epub ahead of print. PMID: 36410321

Kifude CM, Roberds A, Oyieko J, Ocholla S, Otieno S, Waitumbi JN, Hutter J, Smith H, Copeland NK, Luckhart S, Stewart VA. Initiation of anti-retroviral/Trimethoprim-Sulfamethoxazole therapy in a longitudinal cohort of HIV-1 positive individuals in Western Kenya rapidly decreases asymptomatic malarial parasitemia. Front Cell Infect Microbiol. 2022 Nov 24;12:1025944. doi: 10.3389/fcimb.2022.1025944. PMID: 36506016; PMCID: PMC9729353.

Roberds A, Kifude C, Oyieko J, Ocholla S, Mutunga J, Oullo D, Waga C, Li Z, Luckhart S, Stewart VA. Longitudinal impact of asymptomatic malaria/HIV-1 co-infection on Plasmodium falciparum gametocyte transcript expression and transmission to Anopheles mosquitoes. Front Cell Infect Microbiol. 2022 Sep 16;12:934641. doi: 10.3389/fcimb.2022.934641. PMID: 36189366; PMCID: PMC9523792.

Thakre N, Simão Gurge RM, Isoe J, Kivi H, Strickland J, Delacruz LR, Rodriguez AM, Haney R, Sadeghi R, Joy T, Chen M, Luckhart S, Riehle MA. Manipulation of pantothenate kinase in Anopheles stephensi suppresses pantothenate levels with minimal impacts on mosquito fitness. Insect Biochem Mol Biol. 2022 Oct;149:103834. doi: 10.1016/j.ibmb.2022.103834. Epub 2022 Sep 7. PMID: 36087890; PMCID: PMC9595603.

Donnelly EL, Céspedes N, Hansten G, Wagers D, Briggs AM, Lowder C, Schauer J, Haapanen L, Van de Water J, Luckhart S. The basophil IL-18 receptor precisely regulates the host immune response and malaria-induced intestinal permeability and alters parasite transmission to mosquitoes without effect on gametocytemia. Immunohorizons. 2022 Aug 19;6(8):630-641. doi: 10.4049/immunohorizons.2200057. PMID: 35985797. 

Donnelly EL, Céspedes N, Hansten G, Wagers D, Briggs AM, Lowder C, Schauer J, Garrison SM, Haapanen L, Van de Water J, Luckhart S. Basophil depletion alters host immunity, intestinal permeability, and mammalian host-to-mosquito transmission in malaria. Immunohorizons. 2022 Aug 15;6(8):581-599. doi: 10.4049/immunohorizons.2200055. PMID: 35970557. 

Briggs AM, Hambly MG, Simão-Gurge RM, Garrison SM, Khaku Z, Van Susteren G, Lewis EE, Riffell JA, Luckhart S. Anopheles stephensi Feeding, Flight Behavior, and Infection With Malaria Parasites are Altered by Ingestion of Serotonin. Front Physiol. 2022;13:911097. doi: 10.3389/fphys.2022.911097. eCollection 2022. PubMed PMID: 35747317; PubMed Central PMCID: PMC9209645.

Trammell CE, Ramirez G, Sanchez-Vargas I, St Clair LA, Ratnayake OC, Luckhart S, Perera R, Goodman AG. Coupled small molecules target RNA interference and JAK/STAT signaling to reduce Zika virus infection in Aedes aegypti. PLoS Pathog. 2022 Apr;18(4):e1010411. doi: 10.1371/journal.ppat.1010411. eCollection 2022 Apr. PubMed PMID: 35377915; PubMed Central PMCID: PMC9017935.

Céspedes N, Donnelly EL, Lowder C, Hansten G, Wagers D, Briggs AM, Schauer J, Haapanen L, Åbrink M, Van de Water J, Luckhart S. Mast Cell Chymase/Mcpt4 Suppresses the Host Immune Response to Plasmodium yoelii, Limits Malaria-Associated Disruption of Intestinal Barrier Integrity and Reduces Parasite Transmission to Anopheles stephensiFront Immunol. 2022;13:801120. doi: 10.3389/fimmu.2022.801120. eCollection 2022. PubMed PMID: 35154114; PubMed Central PMCID: PMC8829543.

Rodriguez AM, Hambly MG, Jandu S, Simão-Gurge R, Lowder C, Lewis EE, Riffell JA, Luckhart S. Histamine Ingestion by Anopheles stephensi Alters Important Vector Transmission Behaviors and Infection Success with Diverse Plasmodium  Species. Biomolecules. 2021; 11(5):719. https://doi.org/10.3390/biom11050719

Hun LV, Cheung KW, Brooks E, Zudekoff R, Luckhart S, Riehle MA. Increased insulin signaling in the Anopheles stephensi fat body regulates metabolism and enhances the host response to both bacterial challenge and Plasmodium falciparum infection. Insect Biochem Mol Biol. 2021 Dec;139:103669. doi: 10.1016/j.ibmb.2021.103669. Epub 2021 Oct 16. PubMed PMID: 34666189; PubMed Central PMCID: PMC8647039.

Donnelly E, de Water JV, Luckhart S. Malaria-induced bacteremia as a consequence of multiple parasite survival strategies. Curr Res Microb Sci. 2021 Dec;2:100036. doi: 10.1016/j.crmicr.2021.100036. eCollection 2021 Dec. Review. PubMed PMID: 34841327; PubMed Central PMCID: PMC8610325.

Kifude C, Stiffler D, Rockabrand D, Miller R, Parsons E, Ocholla S, Dizon NI, Torrevillas BK, Waitumbi J, Oyieko J, Luckhart S, Stewart VA. Asymptomatic falciparum and Non-falciparum Malarial Parasitemia in Adult Volunteers with and without HIV-1 Coinfection in a Cohort Study in Western Kenya. Am J Trop Med Hyg. 2021 Jun 7;105(1):159-166. doi: 10.4269/ajtmh.21-0012. PubMed PMID: 34097645; PubMed Central PMCID: PMC8274768.

Simão-Gurge RM, Thakre N, Strickland J, Isoe J, Delacruz LR, Torrevillas BK, Rodriguez AM, Riehle MA, Luckhart S. Activation of Anopheles stephensi Pantothenate Kinase and Coenzyme A Biosynthesis Reduces Infection with Diverse Plasmodium Species in the Mosquito Host. Biomolecules. 2021 May 29;11(6). doi: 10.3390/biom11060807. PubMed PMID: 34072373; PubMed Central PMCID: PMC8228300.

Andrews KR, Hunter SS, Torrevillas BK, Céspedes N, Garrison SM, Strickland J, Wagers D, Hansten G, New DD, Fagnan MW, Luckhart S. A new mouse SNP genotyping assay for speed congenics: combining flexibility, affordability, and power. BMC Genomics. 2021 May 24;22(1):378. doi: 10.1186/s12864-021-07698-9. PubMed PMID: 34030629; PubMed Central PMCID: PMC8142480.

Rodriguez AM, Hambly MG, Jandu S, Simão-Gurge R, Lowder C, Lewis EE, Riffell JA, Luckhart S. Histamine Ingestion by Anopheles stephensi Alters Important Vector Transmission Behaviors and Infection Success with Diverse Plasmodium Species. Biomolecules. 2021 May 11;11(5). doi: 10.3390/biom11050719. PubMed PMID: 34064869; PubMed Central PMCID: PMC8151525.

Roberds A, Ferraro E, Luckhart S, Stewart VA. HIV-1 Impact on Malaria Transmission: A Complex and Relevant Global Health Concern. Front Cell Infect Microbiol. 2021;11:656938. doi: 10.3389/fcimb.2021.656938. eCollection 2021. Review. PubMed PMID: 33912477; PubMed Central PMCID: PMC8071860.

Tao H, Li L, Liao NS, Schluns KS, Luckhart S, Sleasman JW, Zhong XP. Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development. Front Immunol. 2021;12:623280. doi: 10.3389/fimmu.2021.623280. eCollection 2021. PubMed PMID: 33732245; PubMed Central PMCID: PMC7957058.

Oringanje C, Delacruz LR, Han Y, Luckhart S, Riehle MA. Overexpression of Activated AMPK in the Anopheles stephensi Midgut Impacts Mosquito Metabolism, Reproduction and Plasmodium Resistance. Genes (Basel). 2021 Jan 19;12(1). doi: 10.3390/genes12010119. PubMed PMID: 33478058; PubMed Central PMCID: PMC7835765.

Stiffler DM, Oyieko J, Kifude CM, Rockabrand DM, Luckhart S, Stewart VA. HIV-1 Infection Is Associated With Increased Prevalence and Abundance of Plasmodium falciparum Gametocyte-Specific Transcripts in Asymptomatic Adults in Western Kenya. Front Cell Infect Microbiol. 2020;10:600106. doi: 10.3389/fcimb.2020.600106. eCollection 2020. PubMed PMID: 33614525; PubMed Central PMCID: PMC7892447.

Lee Y, Souvannaseng L, Collier TC, Main BJ, Norris LC, Fofana A, Traoré SF, Cornel AJ, Luckhart S, Lanzaro GC. Evidence for Divergent ion on Immune Genes between the African Malaria Vectors, Anopheles coluzzii and A. gambiaeInsects. 2020 Dec 18;11(12). doi: 10.3390/insects11120893. PubMed PMID: 33352887; PubMed Central PMCID: PMC7767042.

Luckhart S, Riehle MA. Midgut Mitochondrial Function as a Gatekeeper for Malaria Parasite Infection and Development in the Mosquito Host. Front Cell Infect Microbiol. 2020;10:593159. doi: 10.3389/fcimb.2020.593159. eCollection 2020. Review. PubMed PMID: 33363053; PubMed Central PMCID: PMC7759495.

Torrevillas BK, Garrison SM, McKeeken AJ, Patel D, Van Leuven JT, Dizon NI, Rivas KI, Hathaway NJ, Bailey JA, Waitumbi JN, Kifude CM, Oyieko J, Stewart VA, Luckhart S. Plasmodium falciparum DHFR and DHPS Mutations Are Associated With HIV-1 Co-Infection and a Novel DHPS Mutation I504T Is Identified in Western Kenya. Front Cell Infect Microbiol. 2020;10:600112. doi: 10.3389/fcimb.2020.600112. eCollection 2020. PubMed PMID: 33324580; PubMed Central PMCID: PMC7725689.

Taylor DM, Haney RS, Luckhart S. Aquatic Exposure to Abscisic Acid Transstadially Enhances Anopheles stephensi Resistance to Malaria Parasite Infection. Genes (Basel). 2020 Nov 24;11(12). doi: 10.3390/genes11121393. PubMed PMID: 33255333; PubMed Central PMCID: PMC7761407.

Céspedes N, Donnelly E, Garrison S, Haapanen L, Van De Water J, Luckhart S. Nonlethal Plasmodium yoelii Infection Drives Complex Patterns of Th2-Type Host Immunity and Mast Cell-Dependent Bacteremia. Infect Immun. 2020 Nov 16;88(12). doi: 10.1128/IAI.00427-20. Print 2020 Nov 16. PubMed PMID: 32958528; PubMed Central PMCID: PMC7671899.

Taylor DM, Olds CL, Haney RS, Torrevillas BK, Luckhart S. Comprehensive and Durable Modulation of Growth, Development, Lifespan and Fecundity in Anopheles stephensi Following Larval Treatment With the Stress Signaling Molecule and Novel Antimalarial Abscisic Acid. Front Microbiol. 2019;10:3024. doi: 10.3389/fmicb.2019.03024. eCollection 2019. PubMed PMID: 32010091; PubMed Central PMCID: PMC6979008.

Ahlers LRH, Trammell CE, Carrell GF, Mackinnon S, Torrevillas BK, Chow CY, Luckhart S, Goodman AG. Insulin Potentiates JAK/STAT Signaling to Broadly Inhibit Flavivirus Replication in Insect Vectors. Cell Rep. 2019 Nov 12;29(7):1946-1960.e5. doi: 10.1016/j.celrep.2019.10.029. PubMed PMID: 31722209; PubMed Central PMCID: PMC6871768.

Hun LV, Luckhart S, Riehle MA. Increased Akt signaling in the fat body of Anopheles stephensi extends lifespan and increases lifetime fecundity through modulation of insulin-like peptides. J Insect Physiol. 2019 Oct;118:103932. doi: 10.1016/j.jinsphys.2019.103932. Epub 2019 Aug 22. PubMed PMID: 31445957; PubMed Central PMCID: PMC6810901.